Joint involvement
60% untreated patients with previous (mean 6 months) LD (Steere,1987)
asymmetric mono or oligoarticular arthritis (large joint, sometime temporomandibular): joint are swollen -warm but mildly painfull
higher borrelia-specific antibody titers
treatment resistant-arthritis (10%): arthritis persits (knee) despite antibiotic therapy and negative PCR in synovium or joint fluid
(HLA DRB1-0401, auto-immune)