Trivalent vaccine efficacy in mice (1)

• Comparison: 1 µg OspAZS7  vs  0.3 µg OspAZS7 + 0.3 µg OspAZQ1 + 0.3 µg OspAAca1

• Procedure:

  • 3 immunizations (3 weeks interval)
  • Challenge (4 weeks post III) - ticks from Neuchatel area
  • Follow-up infection:
    • culture from skin biopsies (4, 10 weeks post challenge)
    • seroconversion
    • xénodiagnosis

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