Auto-immune arthritis?

• In the hypothesis of Gross et al. (Science 31; 703 (1998)), OspA-induced autoimmune arthritis would be triggered after infection with B. burgdorferi.

BUT

• Molecular mimicry and T-cell cross-reactivity are not enough to explain an autoimmune reaction.
• The requirements to induce an autoimmune disease, as described by Gross et al., are not present after vaccination.

• With LYMErix, there is no clinical evidence of vaccine-induced arthritis.

  • Efficacy trial Lyme 008
  • Post-marketing surveillance

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