Very High Local Concentrations Of Zanamivir In Lung After Inhalation
Surface concentrations correspond to drug concentrations ᡂ µmol/l throughout respiratory tract
Even the subject with the poorest inhalation profile had drug concentrations ɱ µmol/l (1900 ng/ml) within respiratory tract
5 µmol/l is three orders of magnitude greater than the median NA IC50 value (2.9 nmol/l)