Clinical pertinence and usefulness of pharmacodynamics concepts in the clinical use of antibiotics: a global view

Table of Contents

Presentation summary

Factors determining which PK/PD parameters predict or contribute to outcome

PPT Slide

PPT Slide

Adaptation to PK/PD properties

In vivo validation

Antibiotic combinations

1- Development of new compounds (I)

(II)

Example of levofloxacin

2- Clinical relevance 

2.2 Adaptation of dose/dosing

Examples

Examples

Examples

Glycopeptides (cont’d)

3. Short duration (sd) therapy

Examples of ecological impact

Basic requirements

Example of Salmonella infections

Discussion of limitations (I)

Limitations (II)

Conclusions

Email: tulkens@facm.ucl.ac.be

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